Dr. Anas Sarwar Qureshi

Abstract: The present study was designed to explore the short-term therapeutic effect of camel milk (CM) compared to buffalo milk (BM) in Alloxan® induced diabetes in rabbits. Twenty-five female rabbits were divided into five groups (n=5); Placebo (G1), diabetic groups (Alloxan® injected intravenously) including diabetic control (G2), CM @ 40ml/kg (G3), BM@40ml/kg (G4) and glibenclamide (Glicon®) @10mg/kg (G5) orally for 59 days. Blood and serum samples were taken for hematology and biochemical analysis. Kidney and liver tissues were processed by routine paraffin technique. Histologic sections were evaluated for diabetes-induced degenerative changes and antidiabetic effect of camel and buffalo milk. Diabetes showed significant (P≤0.05) impact on all parameters observed in the present study. Camel milk significantly (P≤0.05) recovered diabetic altered hematological (RBC, MCV, Hb, MCH) and serological parameters (AST, ALT, creatinine, BUN, TPs, and TOS). Camel milk and glibenclamide therapy showed more significant (P<<0.01) reduction in blood glucose level as compared to buffalo milk. Microscopic observations demonstrated that camel milk and glibenclamide improved the altered histology of liver and kidneys towards normal. Hence the present work confirms the hypoglycemic effect of CM as well as marked improvement in kidneys and liver function,which was greater than BM fed group.The results indicate that CM have a potential therapeutic effect in the treatment of hyperglycemia and play a significant role in its management as well as reduces the risk of diabetes-related complications.