Dr. Muhammad Ovais Omer

Professor
Pharmacology and Toxicology, Faculty of Bio-Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan
Speech Title: Anti-hyperglycemic and Anti-hyperlipidemic activity of methanol & acetone extracts of Brassica rapa L.

Abstract: Plants have become a great importance as the sources of medicines because of their low toxicity & cost-effectiveness. This study was designed to investigate anti-hyperglycemic & anti-hyperlipidemic effect of methanol and acetone extracts of Brassica rapa L. leaves in diabetic and hperlipidemic mice. Single intraperitoneal injection of alloxan was administered for diabetes induction and cholesterol diet was given for 15 days to induce hyperlipidemia. Nine groups comprising five mice each were used. Group A was control for both diabetes and hyperlipidemia. Group B served as diabetic control. Group C, D, and E received sitagliptin (40mg/kg orally), methanol extract (200mg/kg orally) and acetone extract (200mg/kg orally) respectively for 28 days. Group F served as hyperlipidemic control. Group G, H and I received atorvastatin (20mg/kg orally), methanol extract (200mg/kg orally) and acetone extract (200mg/kg orally) respectively for 35 days. Fasting blood glucose levels were measured at 1st, 14th and 28th day by using glucometer. Blood cholesterol levels were measured at 1st, 5th, 10th and 15th day by using cholesterol meter. One-way ANOVA with turkey-kramer multiple comparison test was used. All treated groups in a dose dependent manner exhibited significant decline in blood glucose & cholesterol levels (p<0.05